Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads
نویسندگان
چکیده
منابع مشابه
The Roads Traveled Our Year Journey
We will be thinking dreaming and breathing statistics in this volume To ensure we retain a balanced perspective on life I refer you to the famous American Robert Frost s well known poem The Road Not Taken see end of this article With apologies to Robert Frost rather than focusing on roads not taken we shall brie y consider instead roads we have taken or The Roads Traveled over the year journey ...
متن کاملInterferon Gamma Receptor: The Beginning of the Journey
Our view of endocytosis and membrane trafficking of transmembrane receptors has dramatically changed over the last 20 years. Several new endocytic routes have been discovered and mechanistically characterized in mammalian cells. Long considered as a passive means to terminate signaling through down-regulation of the number of activated receptors at the plasma membrane, it is now established tha...
متن کاملCross-talk of PGD2 receptors: the DP receptor modulates signaling and trafficking of CRTH2
Background Prostaglandin (PG) D2 is substantially involved in allergic inflammation and signals via the seven transmembrane (7TM) spanning/G protein-coupled receptors (GPCRs) chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) and D-type prostanoid (DP) receptor. Both receptors are co-expressed in eosinophils among other immune cells and have emerged as therapeutic targe...
متن کاملThe neurotrophin receptor signaling endosome: Where trafficking meets signaling.
Neurons are the largest cells in the body and form subcellular compartments such as axons and dendrites. During both development and adulthood building blocks must be continually trafficked long distances to maintain the different regions of the neuron. Beyond building blocks, signaling complexes are also transported, allowing for example, axons to communicate with the soma. The critical roles ...
متن کاملThe many roads to cross-presentation
Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes (CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system, in which the machinery required for peptide ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2021
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.615603